25. February 2016, 16:15 p.m.

Ernst-Abbe-Platz 2, seminar room 3423

Theoretical Analysis of NAD-biosynthesis and -consumption

Prof. Dr. Ines Heiland
(UiT The Arctic University of Norway, Tromsö)

NAD is central to both metabolism and signalling. While in the context of metabolism, NAD is reversible interconverted between its oxidized and reduced form, MAD-depending signalling reactions, lead to the degradation of NAD to its precursor nicotinamide that then needs to be recycled to NAD again.

We combine mathematical modelling and classical bioinformatic approaches to theoretical analyse NAD-biosynthesis and -consumption and have been able to predict the physiological consequences of disease and age-related changes of the pathway.