6 November 2012, 18:00
Ernst-Abbe-Platz 2, seminar room 3423

Dynamic mTOR network models reveal complex mTORC2 and AMPK regulation

Dr. Kathrin Thedieck (Laboratory for Bioinformatics and Molecular Genetics, Albert-Ludwigs-University of Freiburg)

Mammalian target of rapamycin (mTOR) kinase is a central regulator of cellular growth and metabolism and plays an important role in ageing and age-related disease. mTOR is part of two structurally and functionally distinct multiprotein complexes, mTOR complex 1 (mTORC1) and mTORC2. While upstream signalling leading to mTORC1 activation is well understood, pathways leading to mTORC2 induction remain largely elusive. Here, we present a novel combined experimental-computational approach to address mTORC2 upstream regulation. Furthermore, we elucidate a novel mechanism of AMPK activation.