Seminar, 19 April 2012, D. Frishman

19 April 2012, 18:00
Ernst-Abbe-Platz 2, seminar room 3423

Phosphoproteomics in space and time

Prof. Dr. Dmitrij Frishman (Department of Genome-Oriented Bioinformatics, Technical University of Munich)

Protein phosphorylation has by now often been studied on a large scale in a quantitative manner. By contrast, structural properties of identified phosphorylation sites have so far been investigated in a static non-quantitative way. We have combined for the first time dynamic properties of the phosphoproteome with structural features. I will describe how the variation of the amount of phosphorylation correlates with the protein structure in the vicinity of the modified site at six time points of the human cell division cycle.  In the second part of my talk I will present a principal component analysis of 16 genomic variables from Saccharomyces cerevisiae. I will discuss interesting correlations between evolutionary and phenotypic properties of genes, including  phosphorylation density and structural disorder.